Biotin and derivatives
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | MFCD21363287 | 98.0% | 884.92 | C38H64N2O21 | 10 MG
Bis-PEG13-NHS ester is a PEG/alkyl/ether-based bifunctional linker bearing NHS ester reactive groups for conjugation to primary amines. It is used as a cleavable linker for antibody-drug conjugates and as a linker in PROTAC synthesis to enable targeted bioconjugation and protein degradation.
- Contains two NHS ester reactive groups for conjugation to primary amines.
- Suitable as cleavable linker for antibody-drug conjugates and PROTAC synthesis.
- High purity, typically 98.0%.
- Molecular weight 884.92 and formula C38H64N2O21.
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC MeCY5-NHS ester triethylamine | 00-00-0 | 95.3% | C42H56N4O10S2 | 10MG
The triethylamine salt of a Cy5-family N-hydroxysuccinimide (NHS) ester for covalent fluorescent labeling of biomolecules. It reacts with primary amines on proteins, peptides, and oligonucleotides to form stable amide linkages, enabling far-red fluorescence detection in imaging and biochemical assays. The reagent is supplied in research-scale vials for conjugation workflows.
- Reacts with primary amines to form stable amide bonds.
- Suitable for labeling proteins, peptides, and oligonucleotides.
- Cy5-family fluorophore for far-red detection.
- Supplied as a triethylamine salt for handling and solubility.
- Available in small pack sizes for research use.
- Purity 95.3%.
![Medchemexpress LLC N-[6-(biotinamido)hexyl]-3-(2-pyridyldithio)propionamide | 129179-83-5 | MFCD00078541 | 99.7% | C24H37N5O3S3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259744.png-250.jpg)
Medchemexpress LLC N-[6-(biotinamido)hexyl]-3-(2-pyridyldithio)propionamide | 129179-83-5 | MFCD00078541 | 99.7% | C24H37N5O3S3 | 10MG
Biotin-HPDP is a thiol-reactive biotinylation reagent that labels free protein thiols through a cleavable disulfide linkage, enabling reversible biotinylation for affinity purification and recovery of native proteins. It is supplied as a white to off-white solid with high reported purity and defined storage recommendations.
- Thiol-reactive biotinylation reagent for cysteine labeling.
- Cleavable disulfide linkage enables reversible labeling.
- Suitable for affinity purification and protein recovery.
- High reported purity (99.7%).
- Stable as powder at -20°C for long-term storage.
- Available in small pack sizes for biochemical assays.
Medchemexpress LLC 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 250 MG
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker designed for use in the synthesis of PROTACs. These compounds exploit the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins, offering a novel approach for targeted therapy.
- Utilized in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Alkyl/ether-based linker
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 25 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group. It can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Azide group
- Undergoes CuAAc reaction
- Undergoes SPAAC reactions
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | 99.9% | C33H56N4O14S | 25 MG
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Biotin LC hydrazide (biotinamidocaproyl hydrazide) | 109276-34-8 | MFCD00077659 | 99.8% | 371.50 g/mol | C16H29N5O3S | 100 MG
Biotin LC hydrazide is a long-chain biotinylation reagent that reacts with periodate-oxidized glycoproteins and glycans to introduce biotin labels for detection, affinity capture, and conjugation workflows. It is carbohydrate-reactive and reported to be more sensitive than simple biotin hydrazide, improving labeling efficiency in biochemical assays.
- Long-chain hydrazide reagent for labeling oxidized carbohydrates.
- Reacts with periodate-oxidized glycoproteins and glycans.
- Higher sensitivity than biotin hydrazide for improved detection.
- Soluble in DMSO for solution preparation.
- Suitable for biotinylation of proteins, glycans, and nucleic acids.